Hypericum perforatum, commonly known as perforate St. John's wort, is a flowering plant species belonging to the genus Hypericum in the family Hypericaceae. The name "perforate" refers to the tiny translucent dots that appear on the leaves when held up to the light, resembling perforations. In Hebrew, it is known as חלמונית נוקרת (Khalmonit nokeret). Other relevant translations include Millepertuis percé in French, Johanniskraut in German, and hierba de San Juan in Spanish. This perennial herb is native to Europe, western Asia, and North Africa but has spread to many other regions, including North America, where it is considered an invasive species in some areas. H. perforatum is well-known for its bright yellow flowers, which bloom from June to September, and its historical use in traditional medicine for treating various ailments, including wounds, burns, and depression. The plant contains several bioactive compounds, such as hypericin and hyperforin, which are believed to contribute to its medicinal properties. However, it can also interact with numerous medications, leading to potential side effects and contraindications.